The percentage of children who received three doses of the vaccine against diphtheria, tetanus and pertussis (DTP3) fell 5 percentage points between 2019 and 2021 to 81%, causing the largest sustained decline in childhood vaccinations in approximately 30 years. As a result, 25 million children missed out on one or more doses of DTP through routine immunisation services in 2021 alone. This is 2 million more than those who missed out in 2020 and 6 million more than in 2019. The global coverage of the last dose of human papillomavirus (HPV) vaccine, targeting 9-14 years old girls to prevent cervical cancer, was only 12% in 2021.